• Soh Lab 2014
    Soh Lab 2014
  • Soh Lab 2014
    Soh Lab 2014
  • Soh Lab 2012
    Soh Lab 2012
  • Revolutionary aptamer discovery technology
    Revolutionary aptamer discovery technology
  • Real-time in vivo monitoring
    Real-time in vivo monitoring

Welcome to the H. T. Soh Lab

The Soh Laboratory Group at University of California, Santa Barbara works to develop novel materials and devices to improve the condition of human health. Our laboratory consists of researchers from many disciplines, including Physics, Chemistry, and diverse areas of engineering such as Materials, Mechanical, Chemical, and Electrical Engineering. Our current research focuses on two main themes: Directed Evolution of Materials and Integrated Biosensors. These two technologies hold the promise for early detection and personalized treatment for many diseases including Alzheimer’s, cancer, and diabetes.

In the News

  • Faye W. and Kareem's work on P3 (PC-Phone-PCR) system is highlighted in PBS Nova.
  • Faye Walker's work on point-of-care molecular diagnostics has been selected as an ACS Editor's Choice article. Congratulations Faye!
  • Our team receives 2014 Keck Grant Award in Medical Research
  • The Director's Office at the National Institutes of Health (NIH) highlights our lab's work on nucleic acid aptamers. Using DNA for More than Genetic Information.
  • Tracy Chuong and Cayuga Biotech wins second place in the 2014 UCSB New Venture Competition (Tech Push category). Congratulations, Tracy!
  • Diana Wu wins the Dean's Fellowship at UCSB - Congratulations, Diana!!
  • MEDIC attracts the attention of NIH as potential tool for personalized medicine.
  • Professor Soh is inducted as a fellow to American Institute for Medical and Biological Engineering (AIMBE).
  • Nature Magazine highlights our work on real-time biosensors.
  • Our MEDIC technology is showcased on Healthline.com.
  • Chemical and Engineering News highlights our MEDIC technology, calling it "clever with a capital C."
  • The Royal Society of Chemistry's highlights our MEDIC platform.

Recent Publications

  • S-S. Oh, B. Lee, F. Leibfarth, M. Eisenstein, M. Robb, N. Lynd, C. Hawker, and H.T. Soh
    "Synthetic Aptamer-Polymer Hybrid Constructs for Programmed Drug Delivery into Specific Target Cells"
    Journal of the American Chemical Society 50 (82) 12329-12329 (2014)
  • F.M. Walker, K.M. Ahmad, M. Eisenstein, and H.T. Soh
    "Transformation of Personal Computers and Mobile Phones into Genetic Diagnostic Systems"
    Analytical Chemistry 86 (18) 9236-9241 (2014)
  • Y.K Jung, M.A. Woo, H.T. Soh, and H.G. Park
    "Aptamer-Based Cell Imaging Reagents Capable of Fluorescence Switching"
    Chemical Communications 50 (82) 12329-12332 (2014)
  • K.S. Park, S.S. Oh, H.T. Soh, and H.G Park
    "Target-controlled formation of silver nanoclusters in abasic site-incorporated duplex DNA for label-free fluorescent detection of theophylline"
    Nanoscale 6 (17) 9977-9982 (2014)
  • P. Jiang, Z. Hou, N.E. Propson, H.T. Soh, J.A. Thomson, and R.Stewart
    "MPBind: A Meta-Motif Based Statistical Framework and Pipeline to Predict Binding Potential of SELEX-derived Aptamers"
    Bioinformatics 30 (18) 2265-2267 (2014)
  • K. Hsieh, P.L. Mage, A.T. Csordas, M.S. Eisenstein, and H.T. Soh
    "Simultaneous Elimination of Carryover Contamination and Detection of DNA with Uracil-DNA-Glycosylase-Supplemented Loop-Mediated Isothermal Amplification (UDG-LAMP)"
    Chemical Communications 50 (28) 3747-3749 (2014)